Although the studies published since Update are the subject of detailed evaluation here, the committee drew its conclusions in the context of the entire body of literature. Comprehensive longitudinal analyses of the data collected in the six intensive medical examinations—which include data on medical interventions such as hospitalizations and emergency-department visits , cancer incidence, mortality, and exposures—should be conducted to investigate some or all of the health outcomes that may be associated with the exposures under consideration in the present report. Copyright by the National Academy of Sciences. Although about , US women served in the military during the Vietnam War and 5,—7, women served in Vietnam, few data on the health of the deployed and nondeployed female veterans are available.
Cookies automatically authenticate the user. Although the studies published since Update are the subject of detailed evaluation here, the committee drew its conclusions in the context of the entire body of literature. Information garnered from the study could benefit VA and future VAO committees as potential associations between exposure to the chemicals of interest and respiratory outcomes are evaluated. Creative analysis of VA's own data resources may well be the most effective way to address those outcomes and to gain a better understanding of the role of herbicide exposure in development of stroke, prostate cancer, and Parkinson disease in Vietnam veterans. The cohort has been a source of data very valuable in assessing the health effects associated with TCDD exposure, such as data from the recent study of PCP workers with and without TCDD exposure Ruder and Yiin, that is referred to throughout the present report. The NIOSH studies have included high-quality exposure assessment, and evaluations of a wide array of health outcomes have been published. The committee was directed to review the scientific data, not to recommend VA policy; therefore, conclusions reported in Table are not intended to imply or suggest policy decisions. Footnotes 1 Throughout this report, the same alphabetic indicator after year of publication is used consistently for a given reference when there are multiple citations by the same first author in a given year. This information is used to aid in the provision of our various products and services, including customer service, accounting, billing, collections and the marketing of other products and services. The Lung Institute may use aggregate or anonymous information for various uses for itself and third parties. Many additional opportunities for progress in such fields as toxicology, the conduct of continuing or additional epidemiologic studies, and systematic and comprehensive integration of existing data have not been explicitly noted here. The Lung Institute's website may contain links to information at other websites. A strong commitment by the federal government is required to provide sufficient funds to develop the infrastructure necessary to meet the goals of further research that uses these invaluable data and biospecimens. The contribution of recent publications to the evidence database was considerable, but the committee did not weigh them more heavily merely because they were new. National Academies Press; There is a growing body of evidence that TCDD can induce epigenetic changes in animal models, but there are few data that support risk of adverse effects in offspring of men exposed to xenobiotics in general and the VAO chemicals of interest in particular. Another approach could be adopting a case-control structure and exploring whether information about Vietnam exposure or specific herbicide exposure could be ascertained in any of the many birth cohorts that have been established in the last several decades. The scope of potential research on the chemicals is far-reaching, and what follows here is not an exhaustive list of future research that might have value. In addition, new studies should evaluate offspring for defined clinical health conditions that develop later in life, focusing on organ systems that have shown the greatest effects after maternal exposure, including neurologic, immune, and endocrine effects. The convention of assigning the alphabetic indicators in order of citation in a given chapter is not followed. American Journal of Industrial Medicine. The Lung Institute may provide personal information to the Lung Institute's subcontractors and professional advisers which shall be bound by privacy obligations to assist the Lung Institute's uses disclosed herein. On the basis of those information gaps, the present committee favors renewed efforts to conduct epidemiologic studies on all the developmental effects in offspring that may be associated with paternal exposure. Two major information gaps identified by the committee for Update concerning possible association between exposure of male Vietnam veterans to the chemicals of interest and the development of disease in their offspring remain unfilled: Credit card information is used for billing purposes only. They were involved in the handling and distribution of the chemicals in Vietnam. This change made by the current committee to the categorizations determined by the committee for Update as presented in Table is noted in boldface in Table
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